NFL Week 6 kicks off Thursday night, as the Giants host the Eagles.
Here are the lines for every Week 6 matchup at DraftKings Sportsbook as of Oct. 6.
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(All times ET)
2025 NFL Week 6 Odds
THURSDAY, OCT. 9
EAGLES @ GIANTS
Spread: Eagles -7.5
Moneyline: Eagles -380, Giants +300
Over/Under: 42.5
SUNDAY, OCT. 12
BRONCOS @ JETS
Spread: Broncos -7.5
Moneyline: Broncos -380, Jets +300
Over/Under: 43.5
COWBOYS @ PANTHERS
Spread: Cowboys -3.5
Moneyline: Cowboys -198, Panthers +164
Over/Under: 48.5
CHARGERS @ DOLPHINS
Spread: Chargers -5.5
Moneyline: Chargers -250, Dolphins +205
Over/Under: 44.5
CARDINALS @ COLTS
Spread: Colts -5.5
Moneyline: Colts -238, Cardinals +195
Over/Under: 47.5
BROWNS @ STEELERS
Spread: Steelers -4.5
Moneyline: Steelers -245, Browns +200
Over/Under: 37.5
RAMS @ RAVENS
Spread: Rams -8.5
Moneyline: Rams -425, Ravens +330
Over/Under: 45.5
SEAHAWKS @ JAGUARS
Spread: Jaguars -1.5
Moneyline: Jaguars -120, Seahawks +100
Over/Under: 45.5
49ERS @ BUCCANEERS
Spread: Buccaneers -3
Moneyline: Buccaneers -166, 49ers +140
Over/Under: 47.5
TITANS @ RAIDERS
Spread: Raiders -5.5
Moneyline: Raiders -270, Titans +220
Over/Under: 41.5
BENGALS @ PACKERS
Spread: Packers -14
Moneyline: Packers -1000, Bengals +650
Over/Under: 43.5
PATRIOTS @ SAINTS
Spread: Patriots -3.5
Moneyline: Patriots -192, Saints +160
Over/Under: 46.5
LIONS @ CHIEFS
Spread: Chiefs -1.5
Moneyline: Chiefs -120, Lions +100
Over/Under: 49.5
MONDAY, OCT. 13
BILLS @ FALCONS
Spread: Bills -3.5
Moneyline: Bills -198, Falcons +164
Over/Under: 48.5
BEARS @ COMMANDERS
Spread: Commanders -3.5
Moneyline: Commanders -192, Bears +160
Over/Under: 50.5
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