NFL wild-card weekend odds: Lines for every playoff matchup

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The top-seeded Philadelphia Eagles and Kansas City Chiefs, both 14-3, get a well-deserved weekend off as the NFL Super Wild-Card Weekend will be held Saturday through Monday.

And there’s an intriguing first-round matchup as the Dallas Cowboys play at Tom Brady and the Tampa Bay Buccaneers on Monday. The Cowboys are seeking their sixth Super Bowl title but first since the 1995 season. Brady is after his eighth Super Bowl title.

RELATED: Behind the scenes with FOX’s NFL crew

From a betting perspective, the Bills are the largest favorites for the opening weekend of the playoffs. Here’s everything you need to know about the NFL odds for wild-card weekend — the point spread, moneyline and total Over/Under (odds via FOX Bet).

All times ET

SATURDAY’S GAMES

No. 7 Seattle Seahawks (9-8) at No. 2 San Francisco 49ers (13-4), 4: 35 p.m., FOX and FOX Sports App

Point spread: 49ers -10 (49ers favored to win by more than 10 points, otherwise Seahawks cover)

Moneyline:  49ers -500 favorites to win (bet $10 to win $12 total); Seahawks +300 underdogs to win (bet $10 to win $40 total)

Total scoring Over/Under:  43.5 points scored by both teams combined

No. 5 Los Angeles Chargers (10-7) at No. 4 Jacksonville Jaguars (9-8), 8: 15 p.m., NBC

Point spread: Chargers -1.5 (Chargers favored to win by more than 1.5 points, otherwise Jaguars cover)

Moneyline:  Chargers -125 favorites to win (bet $10 to win $18 total); Jaguars +100 underdogs to win (bet $10 to win $20 total)

Total scoring Over/Under:  47 points scored by both teams combined

SUNDAY’S GAMES

No. 7 Miami Dolphins (9-8) at No. 2 Buffalo Bills (13-3), 1: 05 p.m., CBS

Point spread: Bills -10.5 (Bills favored to win by more than 10.5 points, otherwise Dolphins cover)

Moneyline:  Bills -556 favorites to win (bet $10 to win $11.80 total); Dolphins +375 underdogs to win (bet $10 to win $47.50 total)

Total scoring Over/Under:  44.5 points scored by both teams combined

No. 6 New York Giants (9-7-1) at No. 3 Minnesota Vikings (13-4), 4: 40 p.m., FOX and FOX Sports App

Point spread: Vikings -3 (Vikings favored to win by more than 3 points, otherwise Giants cover)

Moneyline:  Vikings -154 favorites to win (bet $10 to win $16.49 total); Giants +120 underdogs to win (bet $10 to win $23 total)

Total scoring Over/Under:  47.5 points scored by both teams combined

No. 6 Baltimore Ravens (10-7) at No. 3 Cincinnati Bengals (12-4), 8: 15 p.m., NBC

Point spread: Bengals -6 (Bengals favored to win by more than 6 points, otherwise Ravens cover)

Moneyline:  Bengals -278 favorites to win (bet $10 to win $13.60 total); Ravens +205 underdogs to win (bet $10 to win $30.50 total)

Total scoring Over/Under:  43.5 points scored by both teams combined

MONDAY’S GAME

No. 5 Dallas Cowboys (12-5) at No. 4 Tampa Bay Buccaneers (8-9), 8: 15 p.m., ABC/ESPN

Point spread: Cowboys -3 (Cowboys favored to win by more than 3 points, otherwise Buccaneers cover)

Moneyline:  Cowboys -154 favorites to win (bet $10 to win $16.49 total); Buccaneers +120 underdogs to win (bet $10 to win $22 total)

Total scoring Over/Under:  45.5 points scored by both teams combined

Divisions multiply bettor’s wager

A shout-out to this bettor who placed an eight-leg parlay on the division champions.

The Buccaneers had the lowest odds among the eight division winners (-300) yet finished with the worst record among the champs (8-9).

The $27 wager at +418033 produced a profit of $112,869.

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