No one likes getting sick. Debilitating illnesses drain your energy and cause all kinds of nasty fluids to come out of your body. If allowed to spread, these diseases can decimate an entire population. As bad as that sounds, fiction is arguably worse.
Writers have fashioned countless crazy plagues across the storytelling realm. Their insane symptoms are obviously great for shock value, but what’s scarier is how plausible these sicknesses sound. When explaining the viruses, creators often use real illnesses as foundations. That inspiration aids in authenticity, but it can also make you paranoid. After seeing such believable pandemics play out onscreen, you start to question whether they could actually happen. Soon, you’ll be afraid to catch a cold.
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10 Red Flu
The Last Ship: What is the Virus? [CLIP] | TNT
The Last Ship (2014–2018) may seem like just a naval action show, but it really revolves around a worldwide pandemic. Dubbed the “Red Flu” by some parties, this disease stems from an ancient plant virus buried in the Arctic. Touch helps transmit it, but you can also get sick from breathing contaminated air. Once infected, you suffer from intense fevers and exhaustion. You then develop grotesque lesions all over your body before your system shuts down. The sickness works quickly and efficiently.
That efficacy lets the virus wipe out most of the globe. It easily erodes entire governments, leaving the world in chaos. As bad as that is, you might be more disgusted at what it does to the survivors. Several cultlike leaders use the crisis to frame themselves as saviors and seize power. As much as it bonds the navy sailors, strife of this scale also brings out the worst of humanity.[10]
9 Vampirism
8 Bloodthirsty Long Tongued Vampires Variants Of Strain TV Series – Explored!
It’s no secret that vampires can bite humans to turn them into other vampires. It only takes reading books like Bram Stoker’s Dracula or Anne Rice’s Interview with the Vampire or watching TV shows like True Blood or Buffy the Vampire Slayer to understand this. However, The Strain (2014–2017) boils that process down to medical science. Rather than fangs, a tendril shoots out of the monster’s mouth and latches onto its victim. It uses this tool to suck blood, but it serves another purpose as well.
Feeding on humans injects wormlike organisms into their systems. These little parasites gradually alter their organs, transforming their targets into hairless husks. Their only purpose is to serve their higher vampire masters. Starting in New York City, this biological warfare is enough to cripple the metropolis, along with the rest of the country. Suffice it to say, these vampires are a far cry from the sexy, sparkling kind.[2]
8 MEV-1
The MEV 1 Virus from Contagion Explored | How the Virus Sidesteps the Immune System and Replicates
It doesn’t take a doctor to know that a film called Contagion (2011) concerns a plague. The title refers to a virus called MEV-1. This illness begins in fruit bats and pigs before jumping to humans. From there, infection from fellows is easy. The disease transfers through close contact. That doesn’t just refer to skin but also sweat, saliva, and breath. The ensuing pandemic is fraught with fever, fatigue, shortness of breath, seizures, and whatever other crippling symptoms you can imagine. After a few agonizing days, the afflicted die. Worse still, the virus maintains that speed on a global scale.
The sickness severely hinders the population. Legions of people are dead before they know it, and the remainder line crowded hospitals, pandemic shelters, and dirty streets. Although MEV-1 isn’t quite enough to topple governments or bring forth an apocalypse, it does breed desperation from both professionals and civilians. No one knows how to isolate the infection or synthesize a cure. Even when the doctors engineer a vaccine, they must figure out a means of distribution. Those hurdles ground the movie in uncomfortable realism, which only makes it more unnerving.[3]
7 Cordyceps
The Infected Explained | The Last of Us (HBO)
While The Strain grounds vampires in medical science, The Last of Us (2023– ) attempts the same for zombies. This post-apocalyptic franchise sees the Cordyceps plant fungus mutate beyond anything on record. It soon evolves enough to infect humans. Starting at their brains, it slowly morphs them into feral beasts—covered in fungal growths and focused only on killing. It goes without saying that bites can transmit the disease, but dead specimens release spores, which are arguably more effective if you breathe them. In short, the human race has no chance.
It’s not surprising that this new form of Cordyceps kills most of the planet’s population. Humanity has no idea how to combat it with science, so the only option is to fight it conventionally. This desperation turns friends and family against each other. Characters must execute their closest allies or risk getting infected themselves. Such ruthless tactics are undoubtedly isolating, but they’re the only way to survive.[4]
6 Catriona Plague
The Catriona Plague – Witcher Lore – Witcher Mythology – Witcher 3 Lore
World-hopping sounds fun, but it presents a grave danger to everyone around. If travelers aren’t careful, they can introduce foreign objects into an environment, throwing off the whole ecosystem. That’s the mistake that Ciri makes in The Witcher series (2019 – ). As she jumps between worlds, she lands in a port afflicted by bubonic plague, specifically the Black Death. The residents suffer from fevers, aches, swelling, and lack of energy. A bug from this forsaken place hitches a ride on the heroine’s clothes as she teleports back, thereby heralding disaster for her own world.
The bug then jumps to a rat on a ship bound for Ciri’s homeland, and the rest is history. The sickness spreads across the Continent with little difficulty. The denizens of this medieval fantasy realm don’t have the knowledge or tools needed to combat it. Although the illness is technically nonfictional, who knows how it could mutate in the face of Elves, Dwarves, and magic? That unpredictable lethality soon fills hospitals to the brim with the dead and dying. In the end, the losses resulting from this “Catriona Plague” rival those of the war shortly before.[5]
5 Heart Virus
How Did Goku Get the Heart Virus? Explained | Dragon Ball Code
This sickness differs from other entries in that it