Cancer treatment with chimeric antigen receptor (CAR)-T cells hasactually attained remarkable remissions in particular hematologic malignancies, and extending the technique to other types of cancer is a secret objective of immunotherapy researchstudy. Solid growths have showed especially challenging duetothefactthat of immunosuppressive systems in the growth microenvironment. Writing in Science, Danino and associates summary a brand-new method for releasing CAR-T cells versus strong growths: usage crafted germs to coat the interior of the growth with a artificial antigen and then reward with CAR-T cells particular for the artificial antigen.
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Aschheim, K. A bacterial help for CAR-T cells. Nat Biotechnol 41, 1521 (2023). https://doi.org/10.1038/s41587-023-02042-w
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DOI: https://doi.org/10.1038/s41587-023-02042-w